Synthesis and evaluation of anti-oxidant and cytotoxic activities of novel 10-undecenoic acid methyl ester based lipoconjugates of phenolic acids

• Naganna Narra,
• Shiva Shanker Kaki,
• Rachapudi Badari Narayana Prasad,
• Sunil Misra,
• Koude Dhevendar,
• Venkateshwarlu Kontham and
• Padmaja V. Korlipara

Beilstein J. Org. Chem. 2017, 13, 26–32, doi:10.3762/bjoc.13.4

• derivatives have been assessed by their IC50 inhibitory values in the proliferation of MDA-MB231, SKOV3, MCF7, DU 145 and HepG2 cancer cell lines. Keywords: anticancer; anti-oxidants; caffeic acid; coumaric acid; ferulic acid; phenolic lipids; sinapic acid; undecenoic acid; Introduction Phenolic compounds

• of phenolic lipids, we have synthesized novel derivatives of phenolic lipids from undecenoic acid where the phenolic acids were linked to the olefinic group of undecenoic acid via a thioamide spacer. Among the various fatty acids reported, 10-undecenoic acid is unique due to its bifunctional nature

• due to different media used for the assays; the DPPH assay is conducted in a polar medium but the linoleic acid oxidation study is conducted in a non-polar environment. Cytotoxic activity As there were studies reported on the cytotoxicity of phenolic lipids, we have further screened the prepared

An expedient synthesis of 5-n-alkylresorcinols and novel 5-n-alkylresorcinol haptens

• Kirsti Parikka and
• Kristiina Wähälä

Beilstein J. Org. Chem. 2009, 5, No. 22, doi:10.3762/bjoc.5.22

• way for the immunochemical detection techniques of alkylresorcinols. Keywords: 5-n-alkylresorcinols; haptens; microwave assisted synthesis; Wittig reaction; Introduction 5-Alk(en)ylresorcinols and related compounds are phenolic lipids present in several families of plants (e.g. Gramineae